Course Time: Mondays 3:00-6:00 July 10- August 164 2017
Alexandria west conference room 508
I. Course Description This course serves as an introduction to biology and biochemistry for biomedical informatics (BMI) students. We will cover basic concepts in genetics, cellular biology, and human health with an emphasis on understanding the literature and lab methodology. The goal of this course is to familiarize students with basic biological systems to allow for better understanding integration into bioinformatics based projects.
II. General Course Format and Procedure A combination of text book chapters, reviews and scientific papers will be assigned for each weekly topic. The first half of each session will be completely lecture-based, focusing on basic biology within that field. The second half will be discussion. During the first half we will review frequently used methods in each field. The discussion session will be spent discussing the readings assigned for that week. A main goal of the discussion sessions is to understand the biology from an informatics perspective and to brainstorm ways to efficiently use computation techniques to analyze these data.
III. Course Readings/Materials Purchase:
The Processes of Life by Lawrence E. Hunter
Books from which select chapters will electronically supplied to you:
Campbell Biology (9th Edition)
Biochemistry (7th Edition) Berg JM, Tymoczko JL and L Stryer
IV. Grade Distribution Class Participation 50% Paper Presentations 50%
V. Class Schedule
Week 1: Introduction to Cellular Biology
Topics covered: Macromolecules, cell organization, membrane structure, Cell cycle, DNA to protein synthesis
Methodology: Microscopy (light, confocal, EM), PCR, gel electrophoresis, Northern blots, Western blots. Model Organisms
Radiolab Cellmates (Audio)
The Processes of Life, Chapters 5-6
Campbell Biology, Chapters 15-17
Week 2: Genomics
Topics covered: DNA structure, replication and genetic inheritance, single gene disorders, next generation sequencing, genetic variation, personalized medicine.
Methodology: Quantitative PCR, microarrays, next generation sequencing and assembly, methylation studies, genome-wide association studies (GWAS).
Radiolab Inheritance (Audio)
Campbell Biology, Chapter 17-18, 21
Bush WS and JH Moore. Chapter 11: Genome-Wide Association Studies. PLoS Comput Biol (2012) 8(12)
The 1000 Genomes Project Consortium. A map of human genome variation from population scale sequencing. Nature (2010) 461:1061-1073