Ethics in Biomedical Research Readings
Scientific Misconduct
Resnik DB. What is Recklessness in Scientific Research? The Frank Sauer Case. Account Res 2017
Begley CG. Six red flags for suspect work. Nature 2013
Culliton B. Coping with Fraud: The Darsee Case. Science 1983
Brainard J. Rethinking Retractions. Science 2018
Gunsalus and Robinson. Nine pitfalls of research misconduct. Nature 2018
Nuzzo R. How scientists fool themselves – and how they can stop. Nature 2015
Fanelli, Costas and Lariviere. Misconduct Policies, Academic Culture and Career Stage, Not Gender or Pressures to Publish, Affect Scientific Integrity. PlosOne 2015
Reardon S. US vaccine researcher sentenced to prison for fraud. Nature 2015
Piller C. Blots on a field? Science 2022
Taylor & Heath. Years after Brigham-Harvard scandal US pours millions into tainted step cell field. (2022) Reuters
Ethical Use of Animals in Research
Fuchs BA & Macrina FL. Use of Animals in Biomedical Experimentation. Scientific Integrity: Text and Cases in Responsible Conduct of Research. 2014
Brill et al. The Symbiotic Relationship Between Scientific Quality and Animal Research Ethics. ILAR Journal. 2021
Mentoring and the Scientific Community
AAMC Compact between Biomedical Graduate Students and Their Research Advisors
Couzin J, Truth and Consequences. Science 2006, 313:1222-1226
Fang and Casadevall. Competitive Science: Is Competition Ruining Science? Infection and Immunity. 2015
Case Study #4. Ethical Conduct in Biomedical Research: A Handbook for Biomedical Graduate Studies Students and Research Fellows. 2004, Third Ed.
NYU Policy on Retention of and Access to Research Data (Reference for Case Study #4)
Frommer WB. Opinion: An Ethical Code for Conferences. The Scientist 2016
Human Subjects and Biospecimens
Holm and Ploug. Genome studies reveal flaws in broad consent. Science 2019
Rubin, P. Indian Givers Phoenix New Times. May 27, 2004.
Shah, H. The DeepMind debacle demands dialogue on data. Nature 2017
Tindana, Paulina, et al. ‘It is an entrustment’: Broad consent for genomic research and biobanks in sub-Saharan Africa. Developing world bioethics 2019
Iyer et at. Ethical challenges for a new generation of early-phase pediatric gene therapy trials. Genetics in Medicine. 2021
Offord C. Study finds reproducibility issues in high-impact cancer papers. The Scientist. 2021
Gymrek M. et al., Identifying Personal Genomes by Surname Inference. Science 2013
Seife C. 23andMe is Terrifying, but not for the reasons the FDA thinks. Scientific American. 2013
Weijer C and Emanuel EJ. Protecting Communities in Biomedical Research. Science 2000
Scientific Writing
Thorp HH, ChatGPT is fun, but not an author. Science 2023
Aliukonis et al., Perish or Publish Dilemma: Challenges to Responsible Authorship. Medicina 2020
Ferguson C, Marcus A and Oransky I. The Peer Review Scam. Nature 2014
Ioannidis, et al., A standardized citation metrics author database annotated for scientific field. PLoS Biology 2019
Primack et al. Co-authors gone bad – how to avoid publishing conflicts. Elsevier 2014
Carvalho. Anonymous Peer Review: Truth or Trolling. Scientific American 2020
International Committee of Medical Journal Editors.
Data Responsibility and AI
Stoyanovich and Khan. We are all AI Comic Vol 1-5
Khan and Stoyanovich. Data Responsibility (Vol 1) Mirror, Mirror.
Khan and Stoyanovich. Data Responsibility (Vol 2) Fairness and Friends.
Awad et al., The Moral Machine experiment. Nature. 2018
Rajkomar et al., Ensuring Fairness in Machine Learning to Advance Health Equity. Annals of Internal Medicine. 2018.
Piano SL. Ethical principles in machine learning and artificial intelligence: cases from the field and possible ways forward. Humanities and Social Sciences Communications 2020
Tomasev et al., AI for social good: unlocking the opportunity for positive impact. Nature Communications. 2020
Diversity and Inclusion and Ethical Leadership
Lewis et al., Getting genetic ancestry right for science and society. Science 2022
Villarosa, Myths about physical racial differences were used to justify slavery – and are still believed by doctors today. New York Times 2019
Goodman. Six Wrongs of Racial Science. Race in 21st Century America 2001
Roberts. The Problem with Race-Based Medicine. TED Talk 2016
Villarosa. A Terrible Price: The Deadline Racial Disparities of Covid-19 in America. New York Times 2020
Societal Responsibility
Farahany et al., The ethics of experimenting with human brain tissue. Nature 2018
Kahn J. The Gene Drive Dilemma: We Can Alter Entire Species, but Should We? The New York Times. 2020
Lander, E. Adopt a moratorium on heritable genome editing. Nature 2019
Zhang S. A Biohacker Regrets Publicly Injecting Himself with CRISPR. The Atlantic. 2018